Name: Dapoxetine HCL
CAS: 119356-77-3
Molecular Formula: C21H23NO.HCl
Molecular Weight: 341.88
Molecular Structure:
Major Functions:
Dapoxetine join the ranks of erectile dysfunction drugs such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra), and some dopamine agonists such as cabergoline (Dostinex) and pramipexole, as drugs which can be used to improve male sexual health. Misuse of these drugs as aphrodisiacs or sexual enhancers in individuals who do not suffer from sexual health problems is also a possibility and there have been some concerns about doctors being pressured to prescribe such drugs off-label to people who do not actually have a medical need for the drug.
Some research has shown Dapoxetine to have a benefit in the treatment of premature ejaculation
The recommended dosage is 60-100mg daily.
We sell the product on bulk basis welcome inquiries from the world. In addition, many of their derivatives are also available at our company, which could not be tested out, the low side effect and obvious performance has won the clients’ reputation.
2008年10月24日星期五
Vardenafil
Name: Vardenafil
CAS: 224785-90-4
ATC Code: G04BE09
PubChem: 110634
DrugBank: APRD00699
Molecular Formula: C23H32N6O4S
Molecular Weight: 488.604g/mol
Bioavailability: 15%
Protein Binding: 95%
Half Life: 4-5 Hours
Metabolism: Hepatic
Excretion: Biliary
Major Functions:
Vardenafil is a PDE5 inhibitor used for treating impotence (erectile dysfunction) that is sold under the trade name Levitra
Structurally, the difference between a vardenafil molecule and the others is a methyl group and a nitrogen atom's position. Vardenafil's relatively short effective time is comparable to sildenafil's.
Dosage:
It is available in 2.5 mg, 5 mg, 10 mg, and 20 mg doses in round orange tablets. The normal starting dose is 10 mg (roughly equivalent to 50 mg of sildenafil). Vardenafil should be taken 1 to 2 hours prior to sexual activity, with a maximum dose frequency of once per day. In some territories, such as the UK, only certain doses may be available, i.e. 5 mg, 10 mg, and 20 mg.
We sell the product on bulk basis welcome inquiries from the world. In addition, many of their derivatives are also available at our company, which could not be tested out, the low side effect and obvious performance has won the clients’ reputation.
CAS: 224785-90-4
ATC Code: G04BE09
PubChem: 110634
DrugBank: APRD00699
Molecular Formula: C23H32N6O4S
Molecular Weight: 488.604g/mol
Bioavailability: 15%
Protein Binding: 95%
Half Life: 4-5 Hours
Metabolism: Hepatic
Excretion: Biliary
Major Functions:
Vardenafil is a PDE5 inhibitor used for treating impotence (erectile dysfunction) that is sold under the trade name Levitra
Structurally, the difference between a vardenafil molecule and the others is a methyl group and a nitrogen atom's position. Vardenafil's relatively short effective time is comparable to sildenafil's.
Dosage:
It is available in 2.5 mg, 5 mg, 10 mg, and 20 mg doses in round orange tablets. The normal starting dose is 10 mg (roughly equivalent to 50 mg of sildenafil). Vardenafil should be taken 1 to 2 hours prior to sexual activity, with a maximum dose frequency of once per day. In some territories, such as the UK, only certain doses may be available, i.e. 5 mg, 10 mg, and 20 mg.
We sell the product on bulk basis welcome inquiries from the world. In addition, many of their derivatives are also available at our company, which could not be tested out, the low side effect and obvious performance has won the clients’ reputation.
Tadalafil
Name: Tadalafil
CAS: 171596-29-5
ATC Code: G04BE08
PubChem: 110635
DrugBank: APRD00071
ChemSpider: 99301
Molecular Formula: C22H19N3O4
Molecular Weight: 389.404g/mol
Bioavailability: Varies
Protein Binding: 94%
Half Life: 17.5 Hours
Metabolism: Hepatic
Excretion: Fecal (60%) and urine (around 30%)
Major Functions:
Tadalafil is an orally administered drug for treating impotence (erectile dysfunction), that initially was developed by the biotechnology company ICOS, and then developed and marketed world-wide as Cialis, by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil (and sildenafil and vardenafil) inhibits PDE5, however, because sexual stimulation is required to initiate the local penile release of nitric oxide, tadalafil's inhibition of PDE5 will have no effect without direct sexual stimulation of the penis. The recommended Cialis starting dose for most men is 10 mg, taken as needed before sexual activity, (but not more than once daily). The dose may be increased to 20 mg or decreased to 5mg, per its efficacy and the man's personal tolerance of the drug. To avoid the inconvenience of a man having to program and plan using Cialis around the time of his anticipated sexual activity, Lilly ICOS began a clinical development program to evaluate the risks and benefits of chronic, once-daily use of the drug. In June 2007, the European Commission approved low-dose (2.5 mg and 5 mg) Cialis to be used as single-daily impotence therapy.
We sell the product on bulk basis welcome inquiries from the world. In addition, many of their derivatives are also available at our company, which could not be tested out, the low side effect and obvious performance has won the clients’ reputation.
CAS: 171596-29-5
ATC Code: G04BE08
PubChem: 110635
DrugBank: APRD00071
ChemSpider: 99301
Molecular Formula: C22H19N3O4
Molecular Weight: 389.404g/mol
Bioavailability: Varies
Protein Binding: 94%
Half Life: 17.5 Hours
Metabolism: Hepatic
Excretion: Fecal (60%) and urine (around 30%)
Major Functions:
Tadalafil is an orally administered drug for treating impotence (erectile dysfunction), that initially was developed by the biotechnology company ICOS, and then developed and marketed world-wide as Cialis, by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil (and sildenafil and vardenafil) inhibits PDE5, however, because sexual stimulation is required to initiate the local penile release of nitric oxide, tadalafil's inhibition of PDE5 will have no effect without direct sexual stimulation of the penis. The recommended Cialis starting dose for most men is 10 mg, taken as needed before sexual activity, (but not more than once daily). The dose may be increased to 20 mg or decreased to 5mg, per its efficacy and the man's personal tolerance of the drug. To avoid the inconvenience of a man having to program and plan using Cialis around the time of his anticipated sexual activity, Lilly ICOS began a clinical development program to evaluate the risks and benefits of chronic, once-daily use of the drug. In June 2007, the European Commission approved low-dose (2.5 mg and 5 mg) Cialis to be used as single-daily impotence therapy.
We sell the product on bulk basis welcome inquiries from the world. In addition, many of their derivatives are also available at our company, which could not be tested out, the low side effect and obvious performance has won the clients’ reputation.
Sildenafil Citrate
Name: Sildenafil Citrate
CAS: 139755-83-2
ATC Code: G04BE03
PubChem: 5281023
DrugBank: APRD00556
ChemSpider: 56586
Molecular Formula: C22H30N6O4S
Molecular Weight: 474.6g/mol
Bioavailability: 40%
Half Life: 3-4 Hours
Metabolism: Hepatic
Excretion: Fecal (80%) and renal (around 13%)
Major Functions:
Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction (male impotence) and pulmonary arterial hypertension (PAH). It was developed and is being marketed by the pharmaceutical company Pfizer. It acts by inhibiting cGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Since becoming available in 1998, sildenafil has been the prime treatment for erectile dysfunction; its primary competitors on the market are tadalafil (Cialis) and vardenafil (Levitra).
Dosage
The dose of sildenafil for erectile dysfunction is 25 mg to 150 mg taken not more than once per day between 30 minutes and 4 hours prior to sexual intercourse. It is usually recommended to start with a dosage of 50 mg (or even 25 mg) and then lower or raise the dosage as appropriate
The preparation steps for synthesis of sildenafil citrate are as follows
Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate.
Hydrolysis with aqueous NaOH to free acid.
Nitration with oleum/fuming nitric acid.
Carboxamide formation with refluxing thionyl chloride/NH4OH.
Reduction of nitro group to amino.
Acylation with 2-ethoxybenzoyl chloride.
Cyclization.
Sulfonation to the chlorosulfonyl derivative.
Condensation with 1-methylpiperazine.
We sell the product on bulk basis welcome inquiries from the world. In addition, many of their derivatives are also available at our company, which could not be tested out, the low side effect and obvious performance has won the clients’ reputation.
CAS: 139755-83-2
ATC Code: G04BE03
PubChem: 5281023
DrugBank: APRD00556
ChemSpider: 56586
Molecular Formula: C22H30N6O4S
Molecular Weight: 474.6g/mol
Bioavailability: 40%
Half Life: 3-4 Hours
Metabolism: Hepatic
Excretion: Fecal (80%) and renal (around 13%)
Major Functions:
Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction (male impotence) and pulmonary arterial hypertension (PAH). It was developed and is being marketed by the pharmaceutical company Pfizer. It acts by inhibiting cGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Since becoming available in 1998, sildenafil has been the prime treatment for erectile dysfunction; its primary competitors on the market are tadalafil (Cialis) and vardenafil (Levitra).
Dosage
The dose of sildenafil for erectile dysfunction is 25 mg to 150 mg taken not more than once per day between 30 minutes and 4 hours prior to sexual intercourse. It is usually recommended to start with a dosage of 50 mg (or even 25 mg) and then lower or raise the dosage as appropriate
The preparation steps for synthesis of sildenafil citrate are as follows
Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate.
Hydrolysis with aqueous NaOH to free acid.
Nitration with oleum/fuming nitric acid.
Carboxamide formation with refluxing thionyl chloride/NH4OH.
Reduction of nitro group to amino.
Acylation with 2-ethoxybenzoyl chloride.
Cyclization.
Sulfonation to the chlorosulfonyl derivative.
Condensation with 1-methylpiperazine.
We sell the product on bulk basis welcome inquiries from the world. In addition, many of their derivatives are also available at our company, which could not be tested out, the low side effect and obvious performance has won the clients’ reputation.
2008年10月21日星期二
Melatonin
Name: Melatonin
Synonym: N-[2-(5-methoxy-1H-indol-3-yl)ethyl] ethanamide
CAS: ：73-31-4
Molecular Formula: C13H16N2O2
Molecular Weight: 232.278
Major Functions:
The use of melatonin as a drug can entrain (synchronize) the circadian clock to environmental cycles and can have beneficial effects for treatment of certain insomnias. Its therapeutic potential may be limited by its short biological half-life, poor bioavailability, and the fact that it has numerous non-specific actions. In recent studies though, prolonged release melatonin has shown good results in treating insomnia.
Products containing melatonin have been available as a dietary supplement in the United States since 1993, and met with good consumer acceptance and enthusiasm. However, over-the-counter sales remain illegal in many other countries including some members of the European Union and New Zealand, and the U.S. Postal Service lists melatonin among items prohibited by Germany.
Studies from Massachusetts Institute of Technology have said that melatonin pills sold as supplements contain three to ten times the amount needed to produce the desirable physiologic nocturnal blood melatonin level for enhancement of sleep. Dosages are designed to raise melatonin levels for several hours to enhance quality of sleep, but some studies suggest that smaller doses (for example 0.3 mg as opposed to 3 mg) are just as effective at improving sleep quality
Synonym: N-[2-(5-methoxy-1H-indol-3-yl)ethyl] ethanamide
CAS: ：73-31-4
Molecular Formula: C13H16N2O2
Molecular Weight: 232.278
Major Functions:
The use of melatonin as a drug can entrain (synchronize) the circadian clock to environmental cycles and can have beneficial effects for treatment of certain insomnias. Its therapeutic potential may be limited by its short biological half-life, poor bioavailability, and the fact that it has numerous non-specific actions. In recent studies though, prolonged release melatonin has shown good results in treating insomnia.
Products containing melatonin have been available as a dietary supplement in the United States since 1993, and met with good consumer acceptance and enthusiasm. However, over-the-counter sales remain illegal in many other countries including some members of the European Union and New Zealand, and the U.S. Postal Service lists melatonin among items prohibited by Germany.
Studies from Massachusetts Institute of Technology have said that melatonin pills sold as supplements contain three to ten times the amount needed to produce the desirable physiologic nocturnal blood melatonin level for enhancement of sleep. Dosages are designed to raise melatonin levels for several hours to enhance quality of sleep, but some studies suggest that smaller doses (for example 0.3 mg as opposed to 3 mg) are just as effective at improving sleep quality
16,17α-Epoxyprogesterone
Name: 16,17α-Epoxyprogesterone
Synonym: 16,17α-Epoxyprogesterone
CAS: 1097-51-4
Molecular Formula: C21H28O2
Molecular Weight: 328.45
Synonym: 16,17α-Epoxyprogesterone
CAS: 1097-51-4
Molecular Formula: C21H28O2
Molecular Weight: 328.45
16-Dehydropregnenolone Acetate
Name: 16-Dehydropregnenolone Acetate
Synonym: 5,16-Pregnadien-3b-ol-20-one acetate
CAS: 979-02-2
Molecular Formula: C23H32O3
Molecular Weight: 356.51
Melting Point: 170-178 ºC
Major Functions: It is used to produce cortin, androgen, estrogen, luteal hormone.
Synonym: 5,16-Pregnadien-3b-ol-20-one acetate
CAS: 979-02-2
Molecular Formula: C23H32O3
Molecular Weight: 356.51
Melting Point: 170-178 ºC
Major Functions: It is used to produce cortin, androgen, estrogen, luteal hormone.
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