2008年10月20日星期一

Galanthamine

Name: Galanthamine
Synonym: (4aS,6R,8aS)-5,6,9,10,11,12- hexahydro-3-methoxy-11- methyl-4aH-[1]benzofuro[3a,3,2-ef] [2]benzazepin-6-ol
CAS: 357-70-0
Molecular Formula: C17H21NO3
Molecular Weight: 287.354 g/mol

Molecular Structure:
Botanical Source: Galanthus woronowii,Voronov’snowdrop
Major Functions:
Galantamine in its pure form is a white powder. Galantamine is a competitive and reversible cholinesterase inhibitor. It is believed it works by enhancing cholinergic function by increasing the concentration of acetylcholine in the brain. The atomics resolution 3D structure of the complex of galantamine and its target, acetylcholinesterase, was recently determined by X-ray crystallography. There is no evidence that galantamine alters the course of the underlying dementing process.Galantamine has also shown activity in modulating the nicotinic cholinergic receptors to increase acetylcholine release

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