Kava lactones（Methysticin）

Name：Kava lactones（Methysticin）
CAS：495-85-2
Botanical Source：Piper methysticum (kava)
Molecular Structure：
Methysticin
R1
-
R2
-
R3
-H
R4
-H

Major Functions:
Effects of kavalactones include mild sedation, a slight numbing of the gums and mouth, and vivid dreams. Kava has been reported to improve cognitive performance and promote a cheerful mood. Muscle relaxant, anaesthetic, and anticonvulsive and anxiolytic effects are thought to result from direct interactions of kavalactones with voltage-gated ion channels. Research currently suggests that kavalactones potentiate GABAA activity but do not alter levels of dopamine and serotonin in the CNS. Heavy, long-term kava use does not cause any reduction of ability in saccade and cognitive tests but is associated with elevated liver enzymes.