Tadalafil

Name: Tadalafil
CAS: 171596-29-5
ATC Code: G04BE08
PubChem: 110635
DrugBank: APRD00071
ChemSpider: 99301
Molecular Formula: C22H19N3O4
Molecular Weight: 389.404g/mol
Bioavailability: Varies
Protein Binding: 94%
Half Life: 17.5 Hours
Metabolism: Hepatic
Excretion: Fecal (60%) and urine (around 30%)
Major Functions:
Tadalafil is an orally administered drug for treating impotence (erectile dysfunction), that initially was developed by the biotechnology company ICOS, and then developed and marketed world-wide as Cialis, by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil (and sildenafil and vardenafil) inhibits PDE5, however, because sexual stimulation is required to initiate the local penile release of nitric oxide, tadalafil's inhibition of PDE5 will have no effect without direct sexual stimulation of the penis. The recommended Cialis starting dose for most men is 10 mg, taken as needed before sexual activity, (but not more than once daily). The dose may be increased to 20 mg or decreased to 5mg, per its efficacy and the man's personal tolerance of the drug. To avoid the inconvenience of a man having to program and plan using Cialis around the time of his anticipated sexual activity, Lilly ICOS began a clinical development program to evaluate the risks and benefits of chronic, once-daily use of the drug. In June 2007, the European Commission approved low-dose (2.5 mg and 5 mg) Cialis to be used as single-daily impotence therapy.

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